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It can be scaled to full production size with the same structure and channel geometries, using Ehrfeld’s own technology or licensed from others.UK-based Syrris has just completed an Innovate UK funded project with GSK and the EPSRC Centre for Continuous Manufacturing and Crystallisation (CMAC) which characterised the heat and mass transfer and mixing capabilities of its modular continuous processing system.”’ Intensichem is working on hydrogenation, continuous melt technology – completely eliminating the solvent for some processes – and oxidation.A smaller plant footprint also means the most appropriate materials can be chosen, for example a corrosion-resistant superalloy such as Hastelloy might otherwise have been prohibitively costly.The same is true in India, where the generics industry has been rocked by a few high profile concerns about quality in recent years.For small to medium scale, chemical makers now have a lot of choice without having to choose bespoke systems. Ehrfeld’s plate-based modular system can be used to demonstrate that a process can run continuously in the lab.The goal is to understand the process more deeply and then pick the appropriate technology for the rate at which you want to manufacture, says Tames.

The evangelists for this emerging technology point to improved yields, less waste, greater purity of the finished product and, in some cases, a safer process.

Good heat transfer is achieved because of the high surface to volume ratio, which means reactions can often run at much lower temperatures than in batch.

Processes can be scaled up by having multiple reactors in parallel.

‘With continuous you have to sit down and ask “What does this process need?

Does it need high temperature and if so, does it need high pressure to contain the solvent system?

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